Does contemporary vancomycin dosing achieve therapeutic targets in a heterogeneous clinical cohort of critically ill patients? Data from the multinational DALI study
Identifieur interne : 003A16 ( Main/Exploration ); précédent : 003A15; suivant : 003A17Does contemporary vancomycin dosing achieve therapeutic targets in a heterogeneous clinical cohort of critically ill patients? Data from the multinational DALI study
Auteurs : Stijn Blot [Belgique] ; Despoina Koulenti [Australie, Grèce] ; Murat Akova [Turquie] ; Matteo Bassetti [Italie] ; Jan J. De Waele [Belgique] ; George Dimopoulos [Grèce] ; Kirsi-Maija Kaukonen [Finlande, Australie] ; Claude Martin [France] ; Philippe Montravers [France] ; Jordi Rello [Espagne] ; Andrew Rhodes [Royaume-Uni] ; Therese Starr [Australie] ; Steven C. Wallis [Australie] ; Jeffrey Lipman [Australie] ; Jason A. Roberts [Australie]Source :
- Critical Care [ 1364-8535 ] ; 2014.
Abstract
The objective of this study was to describe the pharmacokinetics of vancomycin in ICU patients and to examine whether contemporary antibiotic dosing results in concentrations that have been associated with favourable response.
The Defining Antibiotic Levels in Intensive Care (DALI) study was a prospective, multicentre pharmacokinetic point-prevalence study. Antibiotic dosing was as per the treating clinician either by intermittent bolus or continuous infusion. Target trough concentration was defined as ≥15 mg/L and target pharmacodynamic index was defined as an area under the concentration-time curve over a 24-hour period divided by the minimum inhibitory concentration of the suspected bacteria (AUC0–24/MIC ratio) >400 (assuming MIC ≤1 mg/L).
Data of 42 patients from 26 ICUs were eligible for analysis. A total of 24 patients received vancomycin by continuous infusion (57%). Daily dosage of vancomycin was 27 mg/kg (interquartile range (IQR) 18 to 32), and not different between patients receiving intermittent or continuous infusion. Trough concentrations were highly variable (median 27, IQR 8 to 23 mg/L). Target trough concentrations were achieved in 57% of patients, but more frequently in patients receiving continuous infusion (71% versus 39%;
This study demonstrated large interindividual variability in vancomycin pharmacokinetic and pharmacodynamic target attainment in ICU patients. These data suggests that a re-evaluation of current vancomycin dosing recommendations in critically ill patients is needed to more rapidly and consistently achieve sufficient vancomycin exposure.
Url:
DOI: 10.1186/cc13874
PubMed: 24887569
PubMed Central: 4075416
Affiliations:
- Australie, Belgique, Espagne, Finlande, France, Grèce, Italie, Royaume-Uni, Turquie
- Angleterre, Catalogne, Grand Londres, Provence-Alpes-Côte d'Azur, Province de Flandre-Orientale, Île-de-France
- Barcelone, Gand, Londres, Marseille, Paris
- Université de Gand, Université de Londres
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Le document en format XML
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Data from the multinational DALI study</title><author><name sortKey="Blot, Stijn" sort="Blot, Stijn" uniqKey="Blot S" first="Stijn" last="Blot">Stijn Blot</name><affiliation wicri:level="4"><nlm:aff id="I1">Department of Internal Medicine, Faculty of Medicine & Health Science, Ghent University, Sint-Pietersnieuwstraat 25, 9000 Ghent, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Internal Medicine, Faculty of Medicine & Health Science, Ghent University, Sint-Pietersnieuwstraat 25, 9000 Ghent</wicri:regionArea><placeName><region type="province" nuts="2">Province de Flandre-Orientale</region><settlement type="city">Gand</settlement><settlement type="city">Gand</settlement></placeName><orgName type="university">Université de Gand</orgName></affiliation></author><author><name sortKey="Koulenti, Despoina" sort="Koulenti, Despoina" uniqKey="Koulenti D" first="Despoina" last="Koulenti">Despoina Koulenti</name><affiliation wicri:level="1"><nlm:aff id="I2">Burns Trauma and Critical Care Research Centre, The University of Queensland, Butterfield Street, Herston, Brisbane, QLD 4029, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Burns Trauma and Critical Care Research Centre, The University of Queensland, Butterfield Street, Herston, Brisbane, QLD 4029</wicri:regionArea><wicri:noRegion>QLD 4029</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I3">Royal Brisbane and Women’s Hospital, Butterfield Street, Herston, Brisbane, QLD 4006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Royal Brisbane and Women’s Hospital, Butterfield Street, Herston, Brisbane, QLD 4006</wicri:regionArea><wicri:noRegion>QLD 4006</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I4">Attikon University Hospital, 1, Rimini Street, Haidari, 124 62 Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Attikon University Hospital, 1, Rimini Street, Haidari, 124 62 Athens</wicri:regionArea><wicri:noRegion>124 62 Athens</wicri:noRegion></affiliation></author><author><name sortKey="Akova, Murat" sort="Akova, Murat" uniqKey="Akova M" first="Murat" last="Akova">Murat Akova</name><affiliation wicri:level="1"><nlm:aff id="I5">Hacettepe University, School of Medicine, 06100 Sıhhiye, Ankara, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Hacettepe University, School of Medicine, 06100 Sıhhiye, Ankara</wicri:regionArea><wicri:noRegion>Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Bassetti, Matteo" sort="Bassetti, Matteo" uniqKey="Bassetti M" first="Matteo" last="Bassetti">Matteo Bassetti</name><affiliation wicri:level="1"><nlm:aff id="I6">Azienda Ospedaliera Universitaria Santa Maria della Misericordia, Piazzale Santa Maria della Misericordia, 15, 33100 Udine, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Azienda Ospedaliera Universitaria Santa Maria della Misericordia, Piazzale Santa Maria della Misericordia, 15, 33100 Udine</wicri:regionArea><wicri:noRegion>33100 Udine</wicri:noRegion></affiliation></author><author><name sortKey="De Waele, Jan J" sort="De Waele, Jan J" uniqKey="De Waele J" first="Jan J" last="De Waele">Jan J. De Waele</name><affiliation wicri:level="3"><nlm:aff id="I7">Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Ghent University Hospital, De Pintelaan 185, 9000 Ghent</wicri:regionArea><placeName><region type="province" nuts="2">Province de Flandre-Orientale</region><settlement type="city">Gand</settlement></placeName></affiliation></author><author><name sortKey="Dimopoulos, George" sort="Dimopoulos, George" uniqKey="Dimopoulos G" first="George" last="Dimopoulos">George Dimopoulos</name><affiliation wicri:level="1"><nlm:aff id="I4">Attikon University Hospital, 1, Rimini Street, Haidari, 124 62 Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Attikon University Hospital, 1, Rimini Street, Haidari, 124 62 Athens</wicri:regionArea><wicri:noRegion>124 62 Athens</wicri:noRegion></affiliation></author><author><name sortKey="Kaukonen, Kirsi Maija" sort="Kaukonen, Kirsi Maija" uniqKey="Kaukonen K" first="Kirsi-Maija" last="Kaukonen">Kirsi-Maija Kaukonen</name><affiliation wicri:level="1"><nlm:aff id="I8">Helsinki University Central Hospital, Haartmaninkatu 3, 00029 Helsinki, Uusimaa, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Helsinki University Central Hospital, Haartmaninkatu 3, 00029 Helsinki, Uusimaa</wicri:regionArea><wicri:noRegion>Uusimaa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I9">Australian and New Zealand Intensive Care Research Centre (ANZIC RC), Department of Epidemiology and Preventive Medicine, Monash University, 99 Commercial Road, Melbourne, VIC 3004, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Australian and New Zealand Intensive Care Research Centre (ANZIC RC), Department of Epidemiology and Preventive Medicine, Monash University, 99 Commercial Road, Melbourne, VIC 3004</wicri:regionArea><wicri:noRegion>VIC 3004</wicri:noRegion></affiliation></author><author><name sortKey="Martin, Claude" sort="Martin, Claude" uniqKey="Martin C" first="Claude" last="Martin">Claude Martin</name><affiliation wicri:level="1"><nlm:aff id="I10">Hospital Nord, Chemin des Bourrely, 13015 Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Hospital Nord, Chemin des Bourrely, 13015 Marseille</wicri:regionArea><wicri:noRegion>13015 Marseille</wicri:noRegion><placeName><settlement type="city">Marseille</settlement><region type="région" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="I11">AzuRea Group, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>AzuRea Group</wicri:regionArea></affiliation></author><author><name sortKey="Montravers, Philippe" sort="Montravers, Philippe" uniqKey="Montravers P" first="Philippe" last="Montravers">Philippe Montravers</name><affiliation wicri:level="1"><nlm:aff id="I12">Centre Hospitalier Universitaire Bichat-Claude Bernard, AP-HP, Université Paris VII, 46 Rue Henri Huchard, 75018 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Universitaire Bichat-Claude Bernard, AP-HP, Université Paris VII, 46 Rue Henri Huchard, 75018 Paris</wicri:regionArea><wicri:noRegion>75018 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Rello, Jordi" sort="Rello, Jordi" uniqKey="Rello J" first="Jordi" last="Rello">Jordi Rello</name><affiliation wicri:level="1"><nlm:aff id="I13">CIBERES, Vall d'Hebron Institute of Research, Universitat Autonoma de Barcelona, Passeig de la Vall d’Hebron, 119-129, 08035 Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBERES, Vall d'Hebron Institute of Research, Universitat Autonoma de Barcelona, Passeig de la Vall d’Hebron, 119-129, 08035 Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Rhodes, Andrew" sort="Rhodes, Andrew" uniqKey="Rhodes A" first="Andrew" last="Rhodes">Andrew Rhodes</name><affiliation wicri:level="4"><nlm:aff id="I14">St George’s Healthcare NHS Trust and St George’s University of London, Cranmer Terrace, London SW17 0RE, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>St George’s Healthcare NHS Trust and St George’s University of London, Cranmer Terrace, London SW17 0RE</wicri:regionArea><orgName type="university">Université de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Starr, Therese" sort="Starr, Therese" uniqKey="Starr T" first="Therese" last="Starr">Therese Starr</name><affiliation wicri:level="1"><nlm:aff id="I2">Burns Trauma and Critical Care Research Centre, The University of Queensland, Butterfield Street, Herston, Brisbane, QLD 4029, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Burns Trauma and Critical Care Research Centre, The University of Queensland, Butterfield Street, Herston, Brisbane, QLD 4029</wicri:regionArea><wicri:noRegion>QLD 4029</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I3">Royal Brisbane and Women’s Hospital, Butterfield Street, Herston, Brisbane, QLD 4006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Royal Brisbane and Women’s Hospital, Butterfield Street, Herston, Brisbane, QLD 4006</wicri:regionArea><wicri:noRegion>QLD 4006</wicri:noRegion></affiliation></author><author><name sortKey="Wallis, Steven C" sort="Wallis, Steven C" uniqKey="Wallis S" first="Steven C" last="Wallis">Steven C. Wallis</name><affiliation wicri:level="1"><nlm:aff id="I2">Burns Trauma and Critical Care Research Centre, The University of Queensland, Butterfield Street, Herston, Brisbane, QLD 4029, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Burns Trauma and Critical Care Research Centre, The University of Queensland, Butterfield Street, Herston, Brisbane, QLD 4029</wicri:regionArea><wicri:noRegion>QLD 4029</wicri:noRegion></affiliation></author><author><name sortKey="Lipman, Jeffrey" sort="Lipman, Jeffrey" uniqKey="Lipman J" first="Jeffrey" last="Lipman">Jeffrey Lipman</name><affiliation wicri:level="1"><nlm:aff id="I2">Burns Trauma and Critical Care Research Centre, The University of Queensland, Butterfield Street, Herston, Brisbane, QLD 4029, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Burns Trauma and Critical Care Research Centre, The University of Queensland, Butterfield Street, Herston, Brisbane, QLD 4029</wicri:regionArea><wicri:noRegion>QLD 4029</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I3">Royal Brisbane and Women’s Hospital, Butterfield Street, Herston, Brisbane, QLD 4006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Royal Brisbane and Women’s Hospital, Butterfield Street, Herston, Brisbane, QLD 4006</wicri:regionArea><wicri:noRegion>QLD 4006</wicri:noRegion></affiliation></author><author><name sortKey="Roberts, Jason A" sort="Roberts, Jason A" uniqKey="Roberts J" first="Jason A" last="Roberts">Jason A. Roberts</name><affiliation wicri:level="1"><nlm:aff id="I2">Burns Trauma and Critical Care Research Centre, The University of Queensland, Butterfield Street, Herston, Brisbane, QLD 4029, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Burns Trauma and Critical Care Research Centre, The University of Queensland, Butterfield Street, Herston, Brisbane, QLD 4029</wicri:regionArea><wicri:noRegion>QLD 4029</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I3">Royal Brisbane and Women’s Hospital, Butterfield Street, Herston, Brisbane, QLD 4006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Royal Brisbane and Women’s Hospital, Butterfield Street, Herston, Brisbane, QLD 4006</wicri:regionArea><wicri:noRegion>QLD 4006</wicri:noRegion></affiliation></author></analytic><series><title level="j">Critical Care</title><idno type="ISSN">1364-8535</idno><idno type="eISSN">1466-609X</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Introduction</title><p>The objective of this study was to describe the pharmacokinetics of vancomycin in ICU patients and to examine whether contemporary antibiotic dosing results in concentrations that have been associated with favourable response.</p></sec><sec><title>Methods</title><p>The Defining Antibiotic Levels in Intensive Care (DALI) study was a prospective, multicentre pharmacokinetic point-prevalence study. Antibiotic dosing was as per the treating clinician either by intermittent bolus or continuous infusion. Target trough concentration was defined as ≥15 mg/L and target pharmacodynamic index was defined as an area under the concentration-time curve over a 24-hour period divided by the minimum inhibitory concentration of the suspected bacteria (AUC<sub>0–24</sub>/MIC ratio) >400 (assuming MIC ≤1 mg/L).</p></sec><sec><title>Results</title><p>Data of 42 patients from 26 ICUs were eligible for analysis. A total of 24 patients received vancomycin by continuous infusion (57%). Daily dosage of vancomycin was 27 mg/kg (interquartile range (IQR) 18 to 32), and not different between patients receiving intermittent or continuous infusion. Trough concentrations were highly variable (median 27, IQR 8 to 23 mg/L). Target trough concentrations were achieved in 57% of patients, but more frequently in patients receiving continuous infusion (71% versus 39%; <italic>P</italic> = 0.038). Also the target AUC<sub>0–24</sub>/MIC ratio was reached more frequently in patients receiving continuous infusion (88% versus 50%; <italic>P</italic> = 0.008). Multivariable logistic regression analysis with adjustment by the propensity score could not confirm continuous infusion as an independent predictor of an AUC<sub>0–24</sub>/MIC >400 (odds ratio (OR) 1.65, 95% confidence interval (CI) 0.2 to 12.0) or a C<sub>min</sub> ≥15 mg/L (OR 1.8, 95% CI 0.4 to 8.5).</p></sec><sec><title>Conclusions</title><p>This study demonstrated large interindividual variability in vancomycin pharmacokinetic and pharmacodynamic target attainment in ICU patients. These data suggests that a re-evaluation of current vancomycin dosing recommendations in critically ill patients is needed to more rapidly and consistently achieve sufficient vancomycin exposure.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Boucher, H" uniqKey="Boucher H">H Boucher</name></author><author><name sortKey="Miller, Lg" uniqKey="Miller L">LG Miller</name></author><author><name sortKey="Razonable, Rr" uniqKey="Razonable R">RR Razonable</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, C" uniqKey="Liu C">C Liu</name></author><author><name sortKey="Bayer, A" uniqKey="Bayer A">A Bayer</name></author><author><name sortKey="Cosgrove, Se" uniqKey="Cosgrove S">SE Cosgrove</name></author><author><name sortKey="Daum, Rs" uniqKey="Daum R">RS Daum</name></author><author><name sortKey="Fridkin, Sk" uniqKey="Fridkin S">SK Fridkin</name></author><author><name sortKey="Gorwitz, Rj" uniqKey="Gorwitz R">RJ Gorwitz</name></author><author><name sortKey="Kaplan, Sl" uniqKey="Kaplan S">SL Kaplan</name></author><author><name sortKey="Karchmer, Aw" uniqKey="Karchmer A">AW Karchmer</name></author><author><name sortKey="Levine, Dp" uniqKey="Levine D">DP Levine</name></author><author><name sortKey="Murray, Be" uniqKey="Murray B">BE Murray</name></author><author><name sortKey="Rybak, Mj" uniqKey="Rybak M">MJ Rybak</name></author><author><name sortKey="Talan, Da" uniqKey="Talan D">DA Talan</name></author><author><name sortKey="Chambers, Hf" uniqKey="Chambers H">HF Chambers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rybak, Mj" uniqKey="Rybak M">MJ Rybak</name></author><author><name sortKey="Lomaestro, Bm" uniqKey="Lomaestro B">BM Lomaestro</name></author><author><name sortKey="Rotschafer, Jc" uniqKey="Rotschafer J">JC Rotschafer</name></author><author><name sortKey="Moellering, Rc" uniqKey="Moellering R">RC Moellering</name></author><author><name sortKey="Craig, Wa" uniqKey="Craig W">WA Craig</name></author><author><name sortKey="Billeter, M" uniqKey="Billeter M">M Billeter</name></author><author><name sortKey="Dalovisio, Jr" uniqKey="Dalovisio J">JR Dalovisio</name></author><author><name sortKey="Levine, Dp" uniqKey="Levine D">DP Levine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moise Broder, Pa" uniqKey="Moise Broder P">PA Moise-Broder</name></author><author><name sortKey="Forrest, A" uniqKey="Forrest A">A Forrest</name></author><author><name sortKey="Birmingham, Mc" uniqKey="Birmingham M">MC Birmingham</name></author><author><name sortKey="Schentag, Jj" uniqKey="Schentag J">JJ Schentag</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holmes, Ne" uniqKey="Holmes N">NE Holmes</name></author><author><name sortKey="Turnidge, Jd" uniqKey="Turnidge J">JD Turnidge</name></author><author><name sortKey="Munckhof, Wj" uniqKey="Munckhof W">WJ Munckhof</name></author><author><name sortKey="Robinson, Jo" uniqKey="Robinson J">JO Robinson</name></author><author><name sortKey="Korman, Tm" uniqKey="Korman T">TM Korman</name></author><author><name sortKey="O Sullivan, Mv" uniqKey="O Sullivan M">MV O'Sullivan</name></author><author><name sortKey="Anderson, Tl" uniqKey="Anderson T">TL Anderson</name></author><author><name sortKey="Roberts, Sa" uniqKey="Roberts S">SA Roberts</name></author><author><name sortKey="Warren, Sj" uniqKey="Warren S">SJ Warren</name></author><author><name sortKey="Gao, W" uniqKey="Gao W">W Gao</name></author><author><name sortKey="Howden, Bp" uniqKey="Howden B">BP Howden</name></author><author><name sortKey="Johnson, Pd" uniqKey="Johnson P">PD Johnson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kullar, R" uniqKey="Kullar R">R Kullar</name></author><author><name sortKey="Davis, Sl" uniqKey="Davis S">SL Davis</name></author><author><name sortKey="Levine, Dp" uniqKey="Levine D">DP Levine</name></author><author><name sortKey="Rybak, Mj" uniqKey="Rybak M">MJ Rybak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roberts, Ja" uniqKey="Roberts J">JA Roberts</name></author><author><name sortKey="Lipman, J" uniqKey="Lipman J">J Lipman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Udy, Aa" uniqKey="Udy A">AA Udy</name></author><author><name sortKey="Roberts, Ja" uniqKey="Roberts J">JA Roberts</name></author><author><name sortKey="Lipman, J" uniqKey="Lipman J">J Lipman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roberts, Ja" uniqKey="Roberts J">JA Roberts</name></author><author><name sortKey="Paul, Sk" uniqKey="Paul S">SK Paul</name></author><author><name sortKey="Akova, M" uniqKey="Akova M">M Akova</name></author><author><name sortKey="Bassetti, M" uniqKey="Bassetti M">M Bassetti</name></author><author><name sortKey="De Waele, Jj" uniqKey="De Waele J">JJ De Waele</name></author><author><name sortKey="Dimopoulos, G" uniqKey="Dimopoulos G">G Dimopoulos</name></author><author><name sortKey="Kaukonen, K M" uniqKey="Kaukonen K">K-M Kaukonen</name></author><author><name sortKey="Koulenti, D" uniqKey="Koulenti D">D Koulenti</name></author><author><name sortKey="Martin, C" uniqKey="Martin C">C Martin</name></author><author><name sortKey="Montravers, P" uniqKey="Montravers P">P Montravers</name></author><author><name sortKey="Rello, J" uniqKey="Rello J">J Rello</name></author><author><name sortKey="Rhodes, A" uniqKey="Rhodes A">A Rhodes</name></author><author><name sortKey="Starr, T" uniqKey="Starr T">T Starr</name></author><author><name sortKey="Wallis, Sc" uniqKey="Wallis S">SC Wallis</name></author><author><name sortKey="Lipman, J" uniqKey="Lipman J">J Lipman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roberts, Dm" uniqKey="Roberts D">DM Roberts</name></author><author><name sortKey="Roberts, Ja" uniqKey="Roberts J">JA Roberts</name></author><author><name sortKey="Roberts, Ms" uniqKey="Roberts M">MS Roberts</name></author><author><name sortKey="Liu, X" uniqKey="Liu X">X Liu</name></author><author><name sortKey="Nair, P" uniqKey="Nair P">P Nair</name></author><author><name sortKey="Cole, L" uniqKey="Cole L">L Cole</name></author><author><name sortKey="Lipman, J" uniqKey="Lipman J">J Lipman</name></author><author><name sortKey="Bellomo, R" uniqKey="Bellomo R">R Bellomo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jamal, Ja" uniqKey="Jamal J">JA Jamal</name></author><author><name sortKey="Economou, Cj" uniqKey="Economou C">CJ Economou</name></author><author><name sortKey="Lipman, J" uniqKey="Lipman J">J Lipman</name></author><author><name sortKey="Roberts, Ja" uniqKey="Roberts J">JA Roberts</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, J" uniqKey="Li J">J Li</name></author><author><name sortKey="Udy, Aa" uniqKey="Udy A">AA Udy</name></author><author><name sortKey="Kirkpatrick, Cm" uniqKey="Kirkpatrick C">CM Kirkpatrick</name></author><author><name sortKey="Lipman, J" uniqKey="Lipman J">J Lipman</name></author><author><name sortKey="Roberts, Ja" uniqKey="Roberts J">JA Roberts</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roberts, Ja" uniqKey="Roberts J">JA Roberts</name></author><author><name sortKey="Taccone, Fs" uniqKey="Taccone F">FS Taccone</name></author><author><name sortKey="Udy, Aa" uniqKey="Udy A">AA Udy</name></author><author><name sortKey="Vincent, Jl" uniqKey="Vincent J">JL Vincent</name></author><author><name sortKey="Jacobs, F" uniqKey="Jacobs F">F Jacobs</name></author><author><name sortKey="Lipman, J" uniqKey="Lipman J">J Lipman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Udy, Aa" uniqKey="Udy A">AA Udy</name></author><author><name sortKey="Covajes, C" uniqKey="Covajes C">C Covajes</name></author><author><name sortKey="Taccone, Fs" uniqKey="Taccone F">FS Taccone</name></author><author><name sortKey="Jacobs, F" uniqKey="Jacobs F">F Jacobs</name></author><author><name sortKey="Vincent, Jl" uniqKey="Vincent J">JL Vincent</name></author><author><name sortKey="Lipman, J" uniqKey="Lipman J">J Lipman</name></author><author><name sortKey="Roberts, Ja" uniqKey="Roberts J">JA Roberts</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zelenitsky, S" uniqKey="Zelenitsky S">S Zelenitsky</name></author><author><name sortKey="Rubinstein, E" uniqKey="Rubinstein E">E Rubinstein</name></author><author><name sortKey="Ariano, R" uniqKey="Ariano R">R Ariano</name></author><author><name sortKey="Iacovides, H" uniqKey="Iacovides H">H Iacovides</name></author><author><name sortKey="Dodek, P" uniqKey="Dodek P">P Dodek</name></author><author><name sortKey="Mirzanejad, Y" uniqKey="Mirzanejad Y">Y Mirzanejad</name></author><author><name sortKey="Kumar, A" uniqKey="Kumar A">A Kumar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brown, J" uniqKey="Brown J">J Brown</name></author><author><name sortKey="Brown, K" uniqKey="Brown K">K Brown</name></author><author><name sortKey="Forrest, A" uniqKey="Forrest A">A Forrest</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roberts, Ja" uniqKey="Roberts J">JA Roberts</name></author><author><name sortKey="De Waele, Jj" uniqKey="De Waele J">JJ De Waele</name></author><author><name sortKey="Dimopoulos, G" uniqKey="Dimopoulos G">G Dimopoulos</name></author><author><name sortKey="Koulenti, D" uniqKey="Koulenti D">D Koulenti</name></author><author><name sortKey="Martin, C" uniqKey="Martin C">C Martin</name></author><author><name sortKey="Montravers, P" uniqKey="Montravers P">P Montravers</name></author><author><name sortKey="Rello, J" uniqKey="Rello J">J Rello</name></author><author><name sortKey="Rhodes, A" uniqKey="Rhodes A">A Rhodes</name></author><author><name sortKey="Starr, T" uniqKey="Starr T">T Starr</name></author><author><name sortKey="Wallis, Sc" uniqKey="Wallis S">SC Wallis</name></author><author><name sortKey="Lipman, J" uniqKey="Lipman J">J Lipman</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Matzke, Gr" uniqKey="Matzke G">GR Matzke</name></author><author><name sortKey="Mcgory, Rw" uniqKey="Mcgory R">RW McGory</name></author><author><name sortKey="Halstenson, Ce" uniqKey="Halstenson C">CE Halstenson</name></author><author><name sortKey="Keane, Wf" uniqKey="Keane W">WF Keane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taccone, Fs" uniqKey="Taccone F">FS Taccone</name></author><author><name sortKey="Laterre, Pf" uniqKey="Laterre P">PF Laterre</name></author><author><name sortKey="Spapen, H" uniqKey="Spapen H">H Spapen</name></author><author><name sortKey="Dugernier, T" uniqKey="Dugernier T">T Dugernier</name></author><author><name sortKey="Delattre, I" uniqKey="Delattre I">I Delattre</name></author><author><name sortKey="Layeux, B" uniqKey="Layeux B">B Layeux</name></author><author><name sortKey="De Backer, D" uniqKey="De Backer D">D De Backer</name></author><author><name sortKey="Wittebole, X" uniqKey="Wittebole X">X Wittebole</name></author><author><name sortKey="Wallemacq, P" uniqKey="Wallemacq P">P Wallemacq</name></author><author><name sortKey="Vincent, Jl" uniqKey="Vincent J">JL Vincent</name></author><author><name sortKey="Jacobs, F" uniqKey="Jacobs F">F Jacobs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Zanten, Ar" uniqKey="Van Zanten A">AR van Zanten</name></author><author><name sortKey="Polderman, Kh" uniqKey="Polderman K">KH Polderman</name></author><author><name sortKey="Van Geijlswijk, Im" uniqKey="Van Geijlswijk I">IM van Geijlswijk</name></author><author><name sortKey="Van Der Meer, Gy" uniqKey="Van Der Meer G">GY van der Meer</name></author><author><name sortKey="Schouten, Ma" uniqKey="Schouten M">MA Schouten</name></author><author><name sortKey="Girbes, Ar" uniqKey="Girbes A">AR Girbes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taccone, Fs" uniqKey="Taccone F">FS Taccone</name></author><author><name sortKey="Laterre, Pf" uniqKey="Laterre P">PF Laterre</name></author><author><name sortKey="Dugernier, T" uniqKey="Dugernier T">T Dugernier</name></author><author><name sortKey="Spapen, H" uniqKey="Spapen H">H Spapen</name></author><author><name sortKey="Delattre, I" uniqKey="Delattre I">I Delattre</name></author><author><name sortKey="Wittebole, X" uniqKey="Wittebole X">X Wittebole</name></author><author><name sortKey="De Backer, D" uniqKey="De Backer D">D De Backer</name></author><author><name sortKey="Layeux, B" uniqKey="Layeux B">B Layeux</name></author><author><name sortKey="Wallemacq, P" uniqKey="Wallemacq P">P Wallemacq</name></author><author><name sortKey="Vincent, Jl" uniqKey="Vincent J">JL Vincent</name></author><author><name sortKey="Jacobs, F" uniqKey="Jacobs F">F Jacobs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roberts, Ja" uniqKey="Roberts J">JA Roberts</name></author><author><name sortKey="Lipman, J" uniqKey="Lipman J">J Lipman</name></author><author><name sortKey="Blot, S" uniqKey="Blot S">S Blot</name></author><author><name sortKey="Rello, J" uniqKey="Rello J">J Rello</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blot, S" uniqKey="Blot S">S Blot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wysocki, M" uniqKey="Wysocki M">M Wysocki</name></author><author><name sortKey="Delatour, F" uniqKey="Delatour F">F Delatour</name></author><author><name sortKey="Faurisson, F" uniqKey="Faurisson F">F Faurisson</name></author><author><name sortKey="Rauss, A" uniqKey="Rauss A">A Rauss</name></author><author><name sortKey="Pean, Y" uniqKey="Pean Y">Y Pean</name></author><author><name sortKey="Misset, B" uniqKey="Misset B">B Misset</name></author><author><name sortKey="Thomas, F" uniqKey="Thomas F">F Thomas</name></author><author><name sortKey="Timsit, Jf" uniqKey="Timsit J">JF Timsit</name></author><author><name sortKey="Similowski, T" uniqKey="Similowski T">T Similowski</name></author><author><name sortKey="Mentec, H" uniqKey="Mentec H">H Mentec</name></author><author><name sortKey="Mier, L" uniqKey="Mier L">L Mier</name></author><author><name sortKey="Dreyfuss, D" uniqKey="Dreyfuss D">D Dreyfuss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Akers, Ks" uniqKey="Akers K">KS Akers</name></author><author><name sortKey="Cota, Jm" uniqKey="Cota J">JM Cota</name></author><author><name sortKey="Chung, Kk" uniqKey="Chung K">KK Chung</name></author><author><name sortKey="Renz, Em" uniqKey="Renz E">EM Renz</name></author><author><name sortKey="Mende, K" uniqKey="Mende K">K Mende</name></author><author><name sortKey="Murray, Ck" uniqKey="Murray C">CK Murray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vuagnat, A" uniqKey="Vuagnat A">A Vuagnat</name></author><author><name sortKey="Stern, R" uniqKey="Stern R">R Stern</name></author><author><name sortKey="Lotthe, A" uniqKey="Lotthe A">A Lotthe</name></author><author><name sortKey="Schuhmacher, H" uniqKey="Schuhmacher H">H Schuhmacher</name></author><author><name sortKey="Duong, M" uniqKey="Duong M">M Duong</name></author><author><name sortKey="Hoffmeyer, P" uniqKey="Hoffmeyer P">P Hoffmeyer</name></author><author><name sortKey="Bernard, L" uniqKey="Bernard L">L Bernard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rello, J" uniqKey="Rello J">J Rello</name></author><author><name sortKey="Sole Violan, J" uniqKey="Sole Violan J">J Sole-Violan</name></author><author><name sortKey="Sa Borges, M" uniqKey="Sa Borges M">M Sa-Borges</name></author><author><name sortKey="Garnacho Montero, J" uniqKey="Garnacho Montero J">J Garnacho-Montero</name></author><author><name sortKey="Munoz, E" uniqKey="Munoz E">E Munoz</name></author><author><name sortKey="Sirgo, G" uniqKey="Sirgo G">G Sirgo</name></author><author><name sortKey="Olona, M" uniqKey="Olona M">M Olona</name></author><author><name sortKey="Diaz, E" uniqKey="Diaz E">E Diaz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Waele, Jj" uniqKey="De Waele J">JJ De Waele</name></author><author><name sortKey="Danneels, I" uniqKey="Danneels I">I Danneels</name></author><author><name sortKey="Depuydt, P" uniqKey="Depuydt P">P Depuydt</name></author><author><name sortKey="Decruyenaere, J" uniqKey="Decruyenaere J">J Decruyenaere</name></author><author><name sortKey="Bourgeois, M" uniqKey="Bourgeois M">M Bourgeois</name></author><author><name sortKey="Hoste, E" uniqKey="Hoste E">E Hoste</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Golenia, Bs" uniqKey="Golenia B">BS Golenia</name></author><author><name sortKey="Levine, Ar" uniqKey="Levine A">AR Levine</name></author><author><name sortKey="Moawad, Im" uniqKey="Moawad I">IM Moawad</name></author><author><name sortKey="Yeh, Dd" uniqKey="Yeh D">DD Yeh</name></author><author><name sortKey="Arpino, Pa" uniqKey="Arpino P">PA Arpino</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>Belgique</li><li>Espagne</li><li>Finlande</li><li>France</li><li>Grèce</li><li>Italie</li><li>Royaume-Uni</li><li>Turquie</li></country><region><li>Angleterre</li><li>Catalogne</li><li>Grand Londres</li><li>Provence-Alpes-Côte d'Azur</li><li>Province de Flandre-Orientale</li><li>Île-de-France</li></region><settlement><li>Barcelone</li><li>Gand</li><li>Londres</li><li>Marseille</li><li>Paris</li></settlement><orgName><li>Université de Gand</li><li>Université de Londres</li></orgName></list><tree><country name="Belgique"><region name="Province de Flandre-Orientale"><name sortKey="Blot, Stijn" sort="Blot, Stijn" uniqKey="Blot S" first="Stijn" last="Blot">Stijn Blot</name></region><name sortKey="De Waele, Jan J" sort="De Waele, Jan J" uniqKey="De Waele J" first="Jan J" last="De Waele">Jan J. De Waele</name></country><country name="Australie"><noRegion><name sortKey="Koulenti, Despoina" sort="Koulenti, Despoina" uniqKey="Koulenti D" first="Despoina" last="Koulenti">Despoina Koulenti</name></noRegion><name sortKey="Kaukonen, Kirsi Maija" sort="Kaukonen, Kirsi Maija" uniqKey="Kaukonen K" first="Kirsi-Maija" last="Kaukonen">Kirsi-Maija Kaukonen</name><name sortKey="Koulenti, Despoina" sort="Koulenti, Despoina" uniqKey="Koulenti D" first="Despoina" last="Koulenti">Despoina Koulenti</name><name sortKey="Lipman, Jeffrey" sort="Lipman, Jeffrey" uniqKey="Lipman J" first="Jeffrey" last="Lipman">Jeffrey Lipman</name><name sortKey="Lipman, Jeffrey" sort="Lipman, Jeffrey" uniqKey="Lipman J" first="Jeffrey" last="Lipman">Jeffrey Lipman</name><name sortKey="Roberts, Jason A" sort="Roberts, Jason A" uniqKey="Roberts J" first="Jason A" last="Roberts">Jason A. Roberts</name><name sortKey="Roberts, Jason A" sort="Roberts, Jason A" uniqKey="Roberts J" first="Jason A" last="Roberts">Jason A. Roberts</name><name sortKey="Starr, Therese" sort="Starr, Therese" uniqKey="Starr T" first="Therese" last="Starr">Therese Starr</name><name sortKey="Starr, Therese" sort="Starr, Therese" uniqKey="Starr T" first="Therese" last="Starr">Therese Starr</name><name sortKey="Wallis, Steven C" sort="Wallis, Steven C" uniqKey="Wallis S" first="Steven C" last="Wallis">Steven C. Wallis</name></country><country name="Grèce"><noRegion><name sortKey="Koulenti, Despoina" sort="Koulenti, Despoina" uniqKey="Koulenti D" first="Despoina" last="Koulenti">Despoina Koulenti</name></noRegion><name sortKey="Dimopoulos, George" sort="Dimopoulos, George" uniqKey="Dimopoulos G" first="George" last="Dimopoulos">George Dimopoulos</name></country><country name="Turquie"><noRegion><name sortKey="Akova, Murat" sort="Akova, Murat" uniqKey="Akova M" first="Murat" last="Akova">Murat Akova</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Bassetti, Matteo" sort="Bassetti, Matteo" uniqKey="Bassetti M" first="Matteo" last="Bassetti">Matteo Bassetti</name></noRegion></country><country name="Finlande"><noRegion><name sortKey="Kaukonen, Kirsi Maija" sort="Kaukonen, Kirsi Maija" uniqKey="Kaukonen K" first="Kirsi-Maija" last="Kaukonen">Kirsi-Maija Kaukonen</name></noRegion></country><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Martin, Claude" sort="Martin, Claude" uniqKey="Martin C" first="Claude" last="Martin">Claude Martin</name></region><name sortKey="Martin, Claude" sort="Martin, Claude" uniqKey="Martin C" first="Claude" last="Martin">Claude Martin</name><name sortKey="Montravers, Philippe" sort="Montravers, Philippe" uniqKey="Montravers P" first="Philippe" last="Montravers">Philippe Montravers</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="Rello, Jordi" sort="Rello, Jordi" uniqKey="Rello J" first="Jordi" last="Rello">Jordi Rello</name></region></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Rhodes, Andrew" sort="Rhodes, Andrew" uniqKey="Rhodes A" first="Andrew" last="Rhodes">Andrew Rhodes</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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